Sumoylation: Post

Function. edit. SUMO modification of proteins has many functions. Among the most frequent and best studied are protein stability, nuclear-cytosolic transport ... Function · DeSUMOylation · Role in Human Pathology · Role in protein puri

For example, both SUMO2 and SUMO3 were shown to be essential in helping cells to survive through hyperthermic stress by forming polymeric ...

SUMOylation modulates the stability, localization, or activity of proteins, and interplays with the regulation by other PTMs, thereby affecting ...

SUMO modulates protein function through covalent conjugation to lysine residues in a large number of proteins. Once covalently conjugated to a ...

Most functions of SUMO depend on the establishment of non-covalent protein-protein interactions between SUMOylated substrates and their binding ...

SUMO modulates protein function ... Once covalently conjugated to a protein, SUMO often regulates that protein's function by recruiting other cellular proteins.

SUMO is an essential regulator of cell homeostasis when cells encounter environmental stresses such as osmotic shock, hypoxia, heat, oxidative ...

A SUMO protein is a small ubiquitin-related modifier that can attach to target proteins, altering their activity, cellular location, or interactions with other proteins through a series of enzymatic reactions involving E1, E2, and E3 enzymes .