MMP 13 Enzyme And Neuropathy

The upstream regulatory region of the Mmp13 gene contains a number of transcription factor binding sites but it was recently discovered that there is a conserved forkhead response element (FHRE) consensus sequence for FOXO3a in the human, mouse and rat Mm

The results are consistent with a strong correlation between expressions of TGFβ1 and MMP-13 in OA-affected cartilage that TGF-β can upregulate the levels of MMP13 primarily through the SMAD independent pathway, suggesting TGF-β switches fr

摘要 基质金属蛋白酶-13 (MMP-13)是一种胶原酶，通过裂解靶蛋白的肽键来调节细胞外基质 (ECM)的降解，在骨关节炎发生发展过程中主要负责降解关节软骨中的Ⅱ型胶原。在软骨动态平衡过程中，合成代谢反应 (如Ⅱ型胶原的产生)和分解代谢反应 (如MMP-13对软骨结构的破坏)的平衡有助于维持关节软骨的 ...

本文将详细介绍MMP13基因的功能、作用机制、涉及的信号通路以及它与疾病的关系，帮助读者全面理解这一重要的基因。 MMP13基因是什么？ MMP13，全称Matrix Metallopeptidase 13，是一种酶 ，主要负责分解细胞外基质中的各种蛋白质。

Complete information for MMP13 gene (Protein Coding), Matrix Metallopeptidase 13, including: function, proteins, disorders, pathways, orthologs, and expression.

MMP13的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为基质金属蛋白酶（MMP）家族的蛋白质是参与细胞外基质的在正常生理过程，诸如胚胎发育，生殖和组织重塑，以及在疾病过程，如关节炎和转移的击穿。

Matrix metalloproteinase 13 (MMP13) is a hallmark of OA development, and increased MMP13 expression is closely associated with extracellular matrix degradation.