A Question of Life or Death

Evidence indicates that necrosis and apoptosis represent morphologic expressions of a shared biochemical network described as the “apoptosis-necrosis continuum” ...

The goal of this review is to provide a general overview of the current knowledge relating to the various forms of cell death, including apoptosis, necrosis, ...

Apoptosis leads to cell fragmentation and removal by phagocytic cells, whereas necrosis resulted in cell membrane rupture and inflammation (Fig.

Here, we summarize the latest discoveries in the three most well understood modalities of cell death, namely, apoptosis, necroptosis, and pyroptosis.

The goal of this review is to provide a general overview of the current knowledge relating to the various forms of cell death, including apoptosis, necrosis, ...

In fact, recent evidence suggests that the initiation of apoptosis might actively suppress necrosis because activated caspases cleave and inactivate proteins ...

Highlights. Apoptosis and necrosis are the two major modes of cell death. Apoptosis and necrosis were initially considered as mutually exclusive states.

The present review article focuses on the key features of the diverse cell death modes and their assessment methods commonly utilized in research.