2014年4月17日 - Power calculation for case–control association studies (Box 2) involves calculating the genotype (or allele) frequencies in cases and controls, ...
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Chapter 1 Fundamentals 1.1 Motivation for Sample Size Calculations 1.2 Rationale for Sample Size and Power Calculations Example 1.1 Express the confidence interval P (3:1 < < 3:7) = 0:95 in words. Solution: The confidence interval indicates that we ca
2014年4月17日 - As a simple illustrative example, we consider a case–control study that involves a biallelic locus in Hardy–Weinberg equilibrium with allele ...
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Statistical power and significance testing in large-scale genetic studies Pak C. Sham 1, Shaun M. Purcell 2, 3, Affiliations ... Here, we review the principles and applications of significance testing and power calculation, including recently proposed gen
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